What Are The Causes Of FSGS

The causes of FSG are largely unknown. In such cases it is called idiopathic or primary FSGS. But, FSGS does have some known cause.

What are the causes of FSGS?

The main causes of FSGS include two aspects: internal kidney reason and the external kidney reason. When the glomerular epithelial cells are injured due to massive immune complexes deposition. In case of abnormal immune system, people will easily get infections, colds, etc. Then antigens (bacteria, virus) will enter into the body and then combine with antibody, producing immune complex.

The special epitopes in the kidneys can attract the immune complexes, so the immune complexes will flow with blood circulation and deposit in the glomerular capillary loops, which gives rise to segmental hyaline degeneration in the epithelial cells of the glomerulus. As a result, the surface of epithelial cells of the glomerulus is desquamation, and inflammatory mediator continues to invade, leading to the damages of epithelial cells barrier function.

The segmental sclerosis of glomeruli reflects the result of damage reparation of local inflammation. Primary FSGS is often accompanied by the harms of glomrular epithelial cells. The epithelial cells of visceral layer, or you can call it podocyte, plays an important function in the onset of the primary FSGS.

Epithelial cells can produce various kinds of cell factor and growth factor. The increase of synthesis of collagen from epithelial and mesangial cells and also lead to the decrease of degradation, therefore leading to the glomerular sclerosis.

Besides, the high filtration and high perfusion also play an important function in the formation of FSGS.

Other causes

The abnormal length of the ureter that extends into the bladder.

the hereditary forms of FSGS

Reflux nephropathy, in which urine flows back into the kidney.

Secondary to viral infections such as HIV, parvovirus, and hepatitis B.

Glomerulonephritis, which causes the glomeruli to become inflamed.

Heroin or other drug use.

Birth defects of the kidneys.

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