Causes of IgA Nephropathy

IgA Nephropathy brings kinds of troubles in normal life, and it can cause blood and protein in the urine, high blood pressure and edema. Many patients with IgA Nephropathy are confused about the causes of this antoimmune disorder.

The following are the causes of IgA Nephropathy:

1. Infection and Inflammatory reaction
Infection will cause inflammatory reaction inside the body which affects mesangial cells, resulting in secretion of inflammatory cytokines. Finally, massive immune complexes accumulate in the mesangial area of kidney. IgA has strong affinity with glomerular mesangial cells and the combination of them will lead to the phenotype transformation of renal inherent cells and cause IgA Nephropathy.

2. Genetic predisposition
According to the investigation on IgA Nephropathy patients, a part of them show familial aggregation, which means that IgA Nephropathy has hereditary tendency in some degree.

3. Bone morrow disorders
The IgA depositing in the kidneys is bone marrow-derived.

4. Abnormal cellular inflammatory factors
The IgA1 in the mesangial areas will cause the mesangial cells to secrete inflammatory factors and cause extreme inflammatory reaction resulting in damages of renal structure and renal function.

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